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Girardeau

Sleep and emotional memory


Overview

Our team investigates the neural activity occurring during sleep that underlies the normal and pathological processing of emotional memories and anxiety. Our research currently focuses on the interactions between the hippocampus, crucially involved in episodic and spatial memory, and the amygdala, one of the main structures in the network that processes emotions. We want to understand how an emotion is associated to a specific context or event, and how this association is strengthened or weakened during sleep.

Techniques

• Large scale in vivo recordings in freely behaving rodents using multi-site electrodes allowing for the collection of local field potentials (LFPs) and individual spikes of large neuronal populations.
• In vivo optogenetic manipulations of neuronal networks
• Closed-loop recording/manipulation systems where the automatic detection of a neural pattern triggers a perturbation of neural networks in real time.
• Classical and custom rodent behavioral protocols.
• Custom coding for large neuronal data analysis (Matlab)

Team composition

Team Leader : Gabrielle Girardeau (CRCN Inserm, ATIP-Avenir)
• Billel Khouader, PhD student
• Facundo Morici, Post-doc
• Eléonore Pronier, PhD student
• Elise Morice, MC SU
• Anna Ternon, PhD student (ENS)
• Maëlle Christiaens (ENS intern)

Website : girardeaulab.org

Most Recent Publications

Editorial: Functional Aspects of Mesoscopic Brain Oscillations: Insights From in vivo and in vitro Studies.

Çalışkan G, Mikulovic S, Girardeau G.

Front Neural Circuits. 2022 Jul 4;16:960157.

PMID:35860210

Brain neural patterns and the memory function of sleep.

Gabrielle Girardeau, Vitor Lopes-Dos-Santos

Science (2021) 374, 560-564

PMID:34709916

Reactivations of emotional memory in the hippocampus-amygdala system during sleep.

Girardeau G, Inema I, Buzsáki G.

Nat Neurosci. 2017 Nov;20(11):1634-1642.

PMID:28892057

Hippocampo-cortical coupling mediates memory consolidation during sleep.

Nicolas Maingret, Gabrielle Girardeau, Ralitsa Todorova, Marie Goutierre, Michaël Zugaro

Nat Neurosci. 2016 Jul;19(7):959-64.

PMID:27182818

Learning-induced plasticity regulates hippocampal sharp wave-ripple drive.

Gabrielle Girardeau, Anne Cei, Michaël Zugaro

J Neurosci. 2014 Apr 9;34(15):5176-83.

PMID:24719097

Reversed theta sequences of hippocampal cell assemblies during backward travel.

Anne Cei, Gabrielle Girardeau, Céline Drieu, Karim El Kanbi, Michaël Zugaro

Nat Neurosci. 2014 May;17(5):719-24.

PMID:24667574

Hippocampal ripples and memory consolidation.

Gabrielle Girardeau, Michaël Zugaro

Curr Opin Neurobiol. 2011 Jun;21(3):452-9.

PMID:21371881

Selective suppression of hippocampal ripples impairs spatial memory.

Gabrielle Girardeau, Karim Benchenane, Sidney I Wiener, György Buzsáki, Michaël B Zugaro

Nat Neurosci. 2009 Oct;12(10):1222-3.

PMID:19749750

The role of sleep in emotional processing: insights and unknowns from rodent research.

S. Trouche, M.N. Pompili, G. Girardeau.

Op. Physiol. (2020). 15, 230-237

PMID:0

All Team Girardeau's Publications

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