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Groszer

Neurodevelopmental disorders


Translational program

Research

We study neurodevelopmental disorders with the ultimate aim to identify key molecular and cellular mechanisms involved in establishing neuronal circuits underlying social cognition and behavior. We currently focus on the study of transcription factors whose mutations lead to speech and language disorder and to microcephaly and intellectual disability.
We aim to dissect the molecular targets of these transcription factors and their roles in neuronal physiology and behavior. In order to tackle these issues, we employ state of the art complementary methods in molecular genetics, cell biology, electrophysiology and optogenetics in genetic mouse models and human iPSC-derived neurons. Eventually our research should contribute to a better understanding of complex neurodevelopmental syndromes which affect the ‘social brain’ such as autisms or related disorders.

People

  • Matthias Groszer, CRCN Inserm, Principal investigator
  • Hudson Bezerra, Postdoctoral scientist

Most Recent Publications

An Etiological Foxp2 Mutation Impairs Neuronal Gain in Layer VI Cortico-Thalamic Cells through Increased GABAB/GIRK Signaling

Druart M, Groszer M, Le Magueresse C.

J Neurosci. 2020 Oct 28;40(44):8543-8555.

PMID:33020214

Long-term development of human iPSC-derived pyramidal neurons quantified after transplantation into the neonatal mouse cortex.

D’Alessio R, Koukouli F, Blanchard S, Catteau J, Raïs C, Lemonnier T, Féraud O, Bennaceur-Griscelli A, Groszer M, Maskos U.

Dev Biol. 2020 May 1;461(1):86-95.

PMID:31982375

TBR2 coordinates neurogenesis expansion and precise microcircuit organization via Protocadherin 19 in the mammalian cortex.

Lv X, Ren SQ, Zhang XJ, Shen Z, Ghosh T, Xianyu A, Gao P, Li Z, Lin S, Yu Y, Zhang Q, Groszer M, Shi SH.

Nat Commun. 2019 Sep 2;10(1):3946.

PMID:31477701

ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration.

Hirose T, Cabrera-Socorro A, Chitayat D, Lemonnier T, Féraud O, Cifuentes-Diaz C, Gervasi N, Mombereau C, Ghosh T, Stoica L, Bacha JDA, Yamada H, Lauterbach MA, Guillon M, Kaneko K, Norris JW, Siriwardena K, Blasér S, Teillon J, Mendoza-Londono R, Russeau M, Hadoux J, Ito S, Corvol P, Matheus MG, Holden KR, Takei K, Emiliani V, Bennaceur-Griscelli A, Schwartz CE, Nguyen G, Groszer M.

J Clin Invest. 2019 Apr 15;129(5):2145-2162.

PMID:30985297

AUTS2 isoforms control neuronal differentiation.

Monderer-Rothkoff G, Tal N, Risman M, Shani O, Nissim-Rafinia M, Malki-Feldman L, Medvedeva V, Groszer M, Meshorer E, Shifman S.

Mol Psychiatry. 2019 Apr 5.

PMID:30953002

Mice carrying a humanized Foxp2 knock-in allele show region-specific shifts of striatal Foxp2 expression levels.

Schreiweis C, Irinopoulou T, Vieth B, Laddada L, Oury F, Burguière E, Enard W, Groszer M.

Cortex. 2019 Sep;118:212-222.

PMID:30808549

Altered social behavior in mice carrying a cortical Foxp2 deletion.

Medvedeva VP, Rieger MA, Vieth B, Mombereau C, Ziegenhain C, Ghosh T, Cressant A, Enard W, Granon S, Dougherty JD, Groszer M.

Hum Mol Genet. 2019 Mar 1;28(5):701-717.

PMID:30357341

Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes.

Matthew L Kraushar, Barbara Viljetic, H R Sagara Wijeratne, Kevin Thompson, Xinfu Jiao, Jack W Pike, Vera Medvedeva, Matthias Groszer, Megerditch Kiledjian, Ronald P Hart, Mladen-Roko Rasin

J Neurosci. 2015 Aug 5;35(31):10911-26.

PMID:26245956

Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance.

Christiane Schreiweis, Ulrich Bornschein, Eric Burguière, Cemil Kerimoglu, Sven Schreiter, Michael Dannemann, Shubhi Goyal, Ellis Rea, Catherine A French, Rathi Puliyadi, Matthias Groszer, Simon E Fisher, Roger Mundry, Christine Winter, Wulf Hevers, Svante Pääbo, Wolfgang Enard, Ann M Graybiel

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):14253-8.

PMID:25225386

MicroRNAs establish robustness and adaptability of a critical gene network to regulate progenitor fate decisions during cortical neurogenesis.

Tanay Ghosh, Julieta Aprea, Jeannette Nardelli, Hannes Engel, Christian Selinger, Cedric Mombereau, Thomas Lemonnier, Imane Moutkine, Leslie Schwendimann, Martina Dori, Theano Irinopoulou, Alexandra Henrion-Caude, Arndt G Benecke, Sebastian J Arnold, Pierre Gressens, Federico Calegari, Matthias Groszer

Cell Rep. 2014 Jun 26;7(6):1779-88.

PMID:24931612

All Team Groszer's Pubications

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