Neurodevelopmental disorders
Research
We study neurodevelopmental disorders with the ultimate aim to identify key molecular and cellular mechanisms involved in establishing neuronal circuits underlying social cognition and behavior. We currently focus on the study of transcription factors whose mutations lead to speech and language disorder and to microcephaly and intellectual disability.
We aim to dissect the molecular targets of these transcription factors and their roles in neuronal physiology and behavior. In order to tackle these issues, we employ state of the art complementary methods in molecular genetics, cell biology, electrophysiology and optogenetics in genetic mouse models and human iPSC-derived neurons. Eventually our research should contribute to a better understanding of complex neurodevelopmental syndromes which affect the ‘social brain’ such as autisms or related disorders.
People
- Corentin Le Magueresse, PhD, CR2 INSERM, Junior Investigator
- Christiane Schreiweis, PhD, Postdoctoral Scientist
- Thomas Lemonnier, PhD, Postdoctoral Scientist
- Vera Medvedeva, PhD student
Long-term development of human iPSC-derived pyramidal neurons quantified after transplantation into the neonatal mouse cortex.
D’Alessio R, Koukouli F, Blanchard S, Catteau J, Raïs C, Lemonnier T, Féraud O, Bennaceur-Griscelli A, Groszer M, Maskos U.
Dev Biol. 2020 May 1;461(1):86-95.
PMID:31982375 
TBR2 coordinates neurogenesis expansion and precise microcircuit organization via Protocadherin 19 in the mammalian cortex.
Lv X, Ren SQ, Zhang XJ, Shen Z, Ghosh T, Xianyu A, Gao P, Li Z, Lin S, Yu Y, Zhang Q, Groszer M, Shi SH.
Nat Commun. 2019 Sep 2;10(1):3946.
PMID:31477701
ATP6AP2 variant impairs CNS development and neuronal survival to cause fulminant neurodegeneration.
Hirose T, Cabrera-Socorro A, Chitayat D, Lemonnier T, Féraud O, Cifuentes-Diaz C, Gervasi N, Mombereau C, Ghosh T, Stoica L, Bacha JDA, Yamada H, Lauterbach MA, Guillon M, Kaneko K, Norris JW, Siriwardena K, Blasér S, Teillon J, Mendoza-Londono R, Russeau M, Hadoux J, Ito S, Corvol P, Matheus MG, Holden KR, Takei K, Emiliani V, Bennaceur-Griscelli A, Schwartz CE, Nguyen G, Groszer M.
J Clin Invest. 2019 Apr 15;129(5):2145-2162.
PMID:30985297
AUTS2 isoforms control neuronal differentiation.
Monderer-Rothkoff G, Tal N, Risman M, Shani O, Nissim-Rafinia M, Malki-Feldman L, Medvedeva V, Groszer M, Meshorer E, Shifman S.
Mol Psychiatry. 2019 Apr 5.
PMID:30953002
Mice carrying a humanized Foxp2 knock-in allele show region-specific shifts of striatal Foxp2 expression levels.
Schreiweis C, Irinopoulou T, Vieth B, Laddada L, Oury F, Burguière E, Enard W, Groszer M.
Cortex. 2019 Sep;118:212-222.
PMID:30808549
Altered social behavior in mice carrying a cortical Foxp2 deletion.
Medvedeva VP, Rieger MA, Vieth B, Mombereau C, Ziegenhain C, Ghosh T, Cressant A, Enard W, Granon S, Dougherty JD, Groszer M.
Hum Mol Genet. 2019 Mar 1;28(5):701-717.
PMID:30357341
