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Archive des Publications

Mutation of the α-tubulin Tuba1a leads to straighter microtubules and perturbs neuronal migration.

Belvindrah R., Natarajan K., Shabajee P., Bruel-Jungerman E., Bernard J., Goutierre M., Moutkine I., Jaglin X. H., Savariradjane M., Irinopoulou T., Poncer J. C., Janke C., Francis F.
2017 J Cell Biol. 216(8):2443-2461

Schwannomin-interacting Protein 1 Isoform IQCJ-SCHIP1 Is a Multipartner Ankyrin- and Spectrin-binding Protein Involved in the Organization of Nodes of Ranvier.

Martin PM,  Cifuentes-Diaz C, Devaux J,  Garcia M, , Bureau J, Thomasseau S, Klingler E, Girault JA,  Goutebroze L.
2017 J Biol Chem. 2017 10;292(6):2441-2456

Serotonin neurons in a dish.

Gaspar P, Nedelec S.
2016 Nat Biotechnol;34(1):41-2

Combinatorial analysis of developmental cues efficiently converts human pluripotent stem cells into multiple neuronal subtypes.

Maury Y, Côme J, Piskorowski RA, Salah-Mohellibi N, Chevaleyre V, Peschanski M, Martinat C, Nedelec S.
2015 Nat Biotechnol;33 (1):89-96.

Synergistic binding of transcription factors to cell-specific enhancers programs motor neuron identity.

Mazzoni EO, Mahony S, Closser M, Morrison CA, Nedelec S, Williams DJ, An D, Gifford DK, Wichterle H.
2013 Nat Neurosci;16(9):1219-27

Genetically-modified human pluripotent stem cells: new hopes for the understanding and the treatment of neurological diseases?

Nedelec S, Onteniente B, Peschanski M, Martinat C.
2013 Curr Gene Ther;13(2):111-9. Review.

Concentration-dependent requirement for local protein synthesis in motor neuron subtype-specific response to axon guidance cues.

Nédelec S, Peljto M, Shi P, Amoroso MW, Kam LC, Wichterle H.
2012 J Neurosci;32(4):1496-506.

An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming.

Gabut M, Samavarchi-Tehrani P, Wang X, Slobodeniuc V, O’Hanlon D, Sung HK, Alvarez M, Talukder S, Pan Q, Mazzoni EO, Nedelec S, Wichterle H, Woltjen K, Hughes TR, Zandstra PW, Nagy A, Wrana JL, Blencowe BJ.
2011 Cell;147(1):132-46.

Combined microfluidics/protein patterning platform for pharmacological interrogation of axon pathfinding.

Shi P, Nedelec S, Wichterle H, Kam LC.
2010 Lab Chip;10(8):1005-10

Xenotransplantation of embryonic stem cell-derived motor neurons into the developing chick spinal cord.

Wichterle H, Peljto M, Nedelec S.
2009 Methods Mol Biol;482:171-83

Dendritic localization and activity-dependent translation of Engrailed1 transcription factor.

Di Nardo AA, Nedelec S, Trembleau A, Volovitch M, Prochiantz A, Montesinos ML.
2007 Mol Cell Neurosci;35(2):230-6

Morphological and molecular features of the mammalian olfactory sensory neuron axons: What makes these axons so special?

Nedelec S, Dubacq C, Trembleau A.
2005 J Neurocytol;34(1-2):49-64. Review.

[Emx2 in axons: translational functions of homeodomain transcription factors].

Nédélec S, Trembleau A.
2005 Med Sci (Paris);21(3):237-9.

Emx2 homeodomain transcription factor interacts with eukaryotic translation initiation factor 4E (eIF4E) in the axons of olfactory sensory neurons.

Nédélec S, Foucher I, Brunet I, Bouillot C, Prochiantz A, Trembleau A.
2004 Proc Natl Acad Sci U S A;101(29):10815-20.

Thalamic WNT3 Secretion Spatiotemporally Regulates the Neocortical Ribosome Signature and mRNA Translation to Specify Neocortical Cell Subtypes

Kraushar ML, Viljetic B, Wijeratne HR, Thompson K, Jiao X, Pike JW, Medvedeva V, Groszer M, Kiledjian M, Hart RP, Rasin MR.
2015 J Neurosci.5;35(31):10911-26

New therapeutic opportunities for 5-HT2 receptor ligands

Maroteaux L, Ayme-Dietrich E, Aubertin-Kirch G, Banas S, Quentin E, Lawson R, Monassier L.
2016 Pharmacol Ther.S0163-7258(16)30187-5

A plasma membrane microdomain compartmentalizes ephrin-generated cAMP signals to prune developing retinal axon arbors

Averaimo S, Assali A, Ros O, Couvet S, Zagar Y, Genescu I, Rebsam A, Nicol X.
2016 Nat Commun. 3;7:12896

Pulmonary arterial hypertension, bone marrow, endothelial cell precursors and serotonin

Ayme-Dietrich E, Banas SM, Monassier L, Maroteaux L.
2016 Biol Aujourdhui.210(2):79-88

Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain

Fernandez SP, Cauli B, Cabezas C, Muzerelle A, Poncer JC, Gaspar P.
2016 Brain Struct Funct.221(8):4007-4025

Associations of the Intellectual Disability Gene MYT1L with Helix-Loop-Helix Gene Expression, Hippocampus Volume and Hippocampus Activation During Memory Retrieval.

Kepa A, Medina LM, Erk S, Srivastava DP, Fernandes A, Toro R, Lévi S, Ruggeri B, Fernandes C, Degenhardt F, Witt SH, Meyer-Lindenberg A, Poncer JC, Martinot J,Martinot MP, Müller CP, Heinz A, Walter H, Schumann G, Desrivières S.
2017 Neuropsychopharmacology. doi: 10.1038/npp.2017.91. [Epub ahead of print]

Contribution of serotonin to cardiac remodeling associated with hypertensive diastolic ventricular dysfunction in rats.

Ayme-Dietrich E, Marzak H, Lawson R, Mokni W, Wendling O, Combe R, Becker J, El Fertak L, Champy MF, Matz R, Andriantsitohaina R, Doly S, Boutourlinsky K, Maroteaux L, Monassier L.
2015 J Hypertens;33(11):2310-21

Commentary: Chronic SSRI stimulation of astrocytic 5-HT2B receptors change multiple gene expressions/editings and metabolism of glutamate, glucose and glycogen: a potential paradigm shift.

Banas SM, Diaz SL, Doly S, Belmer A, Maroteaux L.
2012 Front Behav Neurosci.5;9:20

Assembly of juxtaparanodes in myelinating DRG culture: Differential clustering of the Kv1/Caspr2 complex and scaffolding protein 4.1B.

Hivert B, Pinatel D, Labasque M, Tricaud N, Goutebroze L, Faivre-Sarrailh C.
2016 Glia.May;64(5):840-52.

Serotonin Modulates Developmental Microglia via 5-HT2B Receptors: Potential Implication during Synaptic Refinement of Retinogeniculate Projections.

Kolodziejczak M, Béchade C, Gervasi N, Irinopoulou T, Banas SM, Cordier C, Rebsam A, Roumier A, Maroteaux L.
2015 ACS Chem Neurosci. 15;6(7):1219-30.

Cell-specific α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonism reveals new insights in the development of parkinson’s disease.

Pelosi A.
2017 Mov Disord.doi: 10.1002/mds.27071. [Epub ahead of print]

Conditional anterograde tracing reveals distinct targeting of individual serotonin cell groups (B5-B9) to the forebrain and brainstem.

Muzerelle A, Scotto-Lomassese S, Bernard JF, Soiza-Reilly M, Gaspar P
2016 Brain Struct Funct. 221(1):535-61.

KCC2 Gates Activity-Driven AMPA Receptor Traffic through Cofilin Phosphorylation.

Chevy Q, Heubl M, Goutierre M, Backer S, Moutkine I, Eugène E, Bloch-Gallego E, Lévi S, Poncer JC.
2015 J Neurosci. 2;35(48):15772-86

Doublecortin (DCX) is not essential for survival and differentiation of newborn neurons in the adult mouse dentate gyrus.

Dhaliwal J, Xi Y, Bruel-Jungerman E, Germain J, Francis F, Lagace DC.
2016 Front Neurosci.11;9:494

An organotypic brain slice preparation from adult patients with temporal lobe epilepsy

Eugène E, Cluzeaud F, Cifuentes-Diaz C, Fricker D, Le Duigou C, Clemenceau S, Baulac M, Poncer JC, Miles R.
2014 J Neurosci Methods.30;235:234-44

Benzodiazepine ligands rapidly influence GABAA receptor diffusion and clustering at hippocampal inhibitory synapses

Lévi S, Le Roux N, Eugène E, Poncer JC.
2015 Neuropharmacology ;88:199-208

MicroRNAs Establish Robustness and Adaptability of a Critical Gene Network to Regulate Progenitor Fate Decisions during Cortical Neurogenesis

Ghosh T, Aprea J, Nardelli J, Engel H, Selinger C, Mombereau C, Lemonnier T, Moutkine I, Schwendimann L, Dori M, Irinopoulou T, Henrion-Caude A, Benecke AG, Arnold SJ, Gressens P, Calegari F, Groszer M
2014 Cell Rep 7(6):1779-88

CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.

Papandréou MJ, Vacher H, Fache MP, Klingler E, Rueda-Boroni F, Ferracci G, Debarnot C, Pipéroglou C, Garcia Del Caño G, Goutebroze L, Dargent B.
2015 J Neurochem. 134(3):527-37.

The cytoskeleton-associated protein SCHIP1 is involved in axon guidance, and is required for piriform cortex and anterior commissure development.

Klingler E, Martin PM, Garcia M, Moreau-Fauvarque C, Falk J, Chareyre F, Giovannini M, Chédotal A, Girault JA, Goutebroze L.
2015 Development.142(11):2026-36

A critical and previously unsuspected role for doublecortin at the neuromuscular junction in mouse and human

Bourgeois F, Messéant J, Kordeli E, Petit JM, Delers P, Bahi-Buisson N, Bernard V, Sigoillot SM, Gitiaux C, Stouffer M, Francis F, Legay C.
2015 Neuromuscul Disord.25(6):461-73

Neuronal migration disorders: Focus on the cytoskeleton and epilepsy

Stouffer MA, Golden JA, Francis F.
2015 Neurobiol Dis.S0969-9961(15)30024-3.

The Impact of Neuroimmune Alterations in Autism Spectrum Disorder

Gottfried C, Bambini-Junior V, Francis F, Riesgo R, Savino W.
2015 Front Psychiatry.9;6:1215.

Bidirectional Control of Synaptic GABAAR Clustering by Glutamate and Calcium

Bannai H, Niwa F, Sherwood MW, Shrivastava AN, Arizono M, Miyamoto A, Sugiura K, Lévi S, Triller A, Mikoshiba K.
2015 Cell Rep.29;13(12):2768-80

Presynaptic But Not Postsynaptic GABA Signaling at Unitary Mossy Fiber Synapses

Cabezas C, Irinopoulou T, Gauvain G, Poncer JC
2012 J Neurosci 32:11835-11840.

Constitutive and Acquired Serotonin Deficiency Alters Memory and Hippocampal Synaptic Plasticity.

Fernandez SP, Muzerelle A, Scotto-Lomassese S, Barik J, Gruart A, Delgado-García JM, Gaspar P.
2017 Neuropsychopharmacology;42(2):512-523

Benzodiazepine ligands rapidly influence GABAA receptor diffusion and clustering at hippocampal inhibitory synapses

Lévi S, Le Roux N, Eugène E, Poncer JC.
2015 Neuropharmacology ;88:199-208

MicroRNAs Establish Robustness and Adaptability of a Critical Gene Network to Regulate Progenitor Fate Decisions during Cortical Neurogenesis

Ghosh T, Aprea J, Nardelli J, Engel H, Selinger C, Mombereau C, Lemonnier T, Moutkine I, Schwendimann L, Dori M, Irinopoulou T, Henrion-Caude A, Benecke AG, Arnold SJ, Gressens P, Calegari F, Groszer M
2014 Cell Rep 7(6):1779-88

CK2-regulated schwannomin-interacting protein IQCJ-SCHIP-1 association with AnkG contributes to the maintenance of the axon initial segment.

Papandréou MJ, Vacher H, Fache MP, Klingler E, Rueda-Boroni F, Ferracci G, Debarnot C, Pipéroglou C, Garcia Del Caño G, Goutebroze L, Dargent B.
2015 J Neurochem. 134(3):527-37.

The cytoskeleton-associated protein SCHIP1 is involved in axon guidance, and is required for piriform cortex and anterior commissure development.

Klingler E, Martin PM, Garcia M, Moreau-Fauvarque C, Falk J, Chareyre F, Giovannini M, Chédotal A, Girault JA, Goutebroze L.
2015 Development.142(11):2026-36

A critical and previously unsuspected role for doublecortin at the neuromuscular junction in mouse and human

Bourgeois F, Messéant J, Kordeli E, Petit JM, Delers P, Bahi-Buisson N, Bernard V, Sigoillot SM, Gitiaux C, Stouffer M, Francis F, Legay C.
2015 Neuromuscul Disord.25(6):461-73

Neuronal migration disorders: Focus on the cytoskeleton and epilepsy

Stouffer MA, Golden JA, Francis F.
2015 Neurobiol Dis.S0969-9961(15)30024-3.

The Impact of Neuroimmune Alterations in Autism Spectrum Disorder

Gottfried C, Bambini-Junior V, Francis F, Riesgo R, Savino W.
2015 Front Psychiatry.9;6:1215.

Bidirectional Control of Synaptic GABAAR Clustering by Glutamate and Calcium

Bannai H, Niwa F, Sherwood MW, Shrivastava AN, Arizono M, Miyamoto A, Sugiura K, Lévi S, Triller A, Mikoshiba K.
2015 Cell Rep.29;13(12):2768-80

Presynaptic But Not Postsynaptic GABA Signaling at Unitary Mossy Fiber Synapses

Cabezas C, Irinopoulou T, Gauvain G, Poncer JC
2012 J Neurosci 32:11835-11840.

Constitutive and Acquired Serotonin Deficiency Alters Memory and Hippocampal Synaptic Plasticity.

Fernandez SP, Muzerelle A, Scotto-Lomassese S, Barik J, Gruart A, Delgado-García JM, Gaspar P.
2017 Neuropsychopharmacology;42(2):512-523

Humanized Foxp2 accelerates learning by enhancing transitions from declarative to procedural performance

Schreiweis C, Bornschein U, Burguière E, Kerimoglu C, Schreiter S, Dannemann M, Goyal S, Rea E, French CA, Puliyadi R, Groszer M, Fisher SE, Mundry R, Winter C, Hevers W, Pääbo S, Enard W, Graybiel AM.
2014 Proc Natl Acad Sci U S A. 30;111(39):14253-8

Serotonin neurons in a dish.

Gaspar P, Nedelec S.
2016 Nat Biotechnol. 8;34(1):41-2

Multiscale single-cell analysis reveals unique phenotypes of raphe 5-HT neurons projecting to the forebrain.

Fernandez SP, Cauli B, Cabezas C, Muzerelle A, Poncer JC, Gaspar P.
2015 Brain Struct Funct. [Epub ahead of print]

The role of primary cilia in corpus callosum formation is mediated by production of the Gli3 repressor.

Laclef C, Anselme I, Besse L, Catala M, Palmyre A, Baas D, Paschaki M, Pedraza M, Métin C, Durand B, Schneider-Maunoury S.
2015 Hum Mol Genet. 1;24(17):4997-5014

Cortical interneurons migrating on a pure substrate of N-cadherin exhibit fast synchronous centrosomal and nuclear movements and reduced ciliogenesis.

Luccardini C, Leclech C, Viou L, Rio JP, Métin C.
2015 Front Cell Neurosci. 3;9:286.

Cilia and neuronal migrations

Métin C
2014 Med Sci;30(11):991-5

Activity dependent mechanisms of visual map formation–from retinal waves to molecular regulators.

Assali A, Gaspar P, Rebsam A.
2014 Semin Cell Dev Biol. 35:136-46

Routes to cAMP: shaping neuronal connectivity with distinct adenylate cyclases

Nicol X, Gaspar P.
2014 Eur J Neurosci 39:1742-1751

Adenosine receptor antagonists including caffeine alter fetal brain development in mice

Silva CG, Metin C, Fazeli W, Machado NJ, Darmopil S, Launay PS, Ghestem A, Nesa MP, Bassot E, Szabo E, Baqi Y, Muller CE, Tome AR, Ivanov A, Isbrandt D, Zilberter Y, Cunha RA, Esclapez M, Bernard C.
2013 Sci Transl Med 5:197ra104.

N-cadherin sustains motility and polarity of future cortical interneurons during tangential migration.

Luccardini C, Hennekinne L, Viou L, Yanagida M, Murakami F, Kessaris N, Ma X, Adelstein RS, Mège RM, Métin C.
2013 J Neurosci. 13;33(46):18149-60

Long-term modifications of epileptogenesis and hippocampal rhythms after prolonged hyperthermic seizures in the mouse

Hamelin S, Pouyatos B, Khalaf R, Chabrol T, Francis F, David O, Depaulis A
2014 Neurobiol Dis. 69:156-68.

Role of the N-terminal region in G protein-coupled receptor functions: negative modulation revealed by 5-HT2B receptor polymorphisms

Belmer A, Doly S, Setola V, Banas SM, Moutkine I, Boutourlinsky K, Kenakin T, Maroteaux L
2014 Mol Pharmacol;85(1):127-38.

Mutations in TUBG1, DYNC1H1, KIF5C and KIF2A cause malformations of cortical development and microcephaly

Poirier K, Lebrun N, Broix L, Tian G, Saillour Y, Boscheron C, Parrini E, Valence S, Pierre BS, Oger M, Lacombe D, Geneviève D, Fontana E, Darra F, Cances C, Barth M, Bonneau D, Bernadina BD, N’guyen S, Gitiaux C, Parent P, des Portes V, Pedespan JM, Legrez V, Castelnau-Ptakine L, Nitschke P, Hieu T, Masson C, Zelenika D, Andrieux A, Francis F, Guerrini R, Cowan NJ, Bahi-Buisson N, Chelly J.
2013 Nat Genet. 45(6):639-47.

Mutations du gène EML1/Eml1, progéniteurs neuronaux et hétérotopies chez l’homme et la souris

Kielar M, Phan Dinh Tuy F, Bizzotto S, Belvindrah R, Croquelois A, Francis F
2014. Med Sci (Paris) 30:1087–1090

Lire la suite

GDM-associated insulin deficiency hinders the dissociation of SERT from ERp44 and down-regulates placental 5-HT uptake.

Li Y, Hadden C, Singh P, Mercado CP, Murphy P, Dajani NK, Lowery CL, Roberts DJ, Maroteaux L, Kilic F.
2014 Proc Natl Acad Sci U S A. 30;111(52):E5697-705

Morphological and functional aspects of progenitors perturbed in cortical malformations.

Bizzotto S, Francis F.
2015 Front Cell Neurosci.12;9:3012;9:30

Beta tubulin isoforms are not interchangeable for rescuing impaired radial migration due to Tubb3 knockdown

Saillour Y, Broix L, Bruel-Jungerman E, Lebrun N, Muraca G, Rucci J, Poirier K, Belvindrah R, Francis F, Chelly J
2014 Hum Mol Genet 23(6):1516-26

Neuronal migration and its disorders affecting the CA3 region

Belvindrah R, Nosten-Bertrand M, Francis F.
2014 Front Cell Neurosci. 8:63.

Control of ALK (wild type and mutated forms) phosphorylation: specific role of the phosphatase PTP1B

Boutterin MC, Mazot P, Faure C, Doly S, Gervasi N, Tremblay ML, Vigny M
2013 Cell Signal 25:1505-1513

Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR-ss/delta in osteoblasts

Chabbi-Achengli Y, Launay JM, Maroteaux L, de Vernejoul MC, Collet C
2013 PLoS One.17;8(9):e75783.

A serotonin-induced N-glycan switch regulates platelet aggregation

Mercado CP, Quintero MV, Li Y, Singh P, Byrd AK, Talabnin K, Ishihara M, Azadi P, Rusch NJ, Kuberan B, Maroteaux L, Kilic F
2013.Sci Rep. 30;3:2795

Overexpression of 5-hydroxytryptamine 2B receptor gene in pulmonary hypertension: still a long way to understand its transcriptional regulation

Maroteaux L
2013 Hypertension;61(4):e28-9.

Transcriptome sequencing during mouse brain development identifies long non-coding RNAs functionally involved in neurogenic commitment

Aprea J, Prenninger S, Dori M, Ghosh T, Monasor LS, Wessendorf E, Zocher S, Massalini S, Alexopoulou D, Lesche M, Dahl A, Groszer M, Hiller M, Calegari F (2013). EMBO J 32:3145-3160.

Genetic disruption of Pten in a novel mouse model of tomaculous neuropathy

Goebbels S, Oltrogge JH, Wolfer S, Wieser GL, Nientiedt T, Pieper A, Ruhwedel T, Groszer M, Sereda MW, Nave KA (2012) . EMBO molecular medicine 4:486-499.

Input-specific learning rules at excitatory synapses onto hippocampal parvalbumin-expressing interneurons

 Le Roux N, Cabezas C, Bohm UL, Poncer JC
2013 J Physiol 591:1809-1822.

Activity-dependent regulation of the K/Cl transporter KCC2 membrane diffusion, clustering, and function in hippocampal neurons

Chamma I, Heubl M, Chevy Q, Renner M, Moutkine I, Eugene E, Poncer JC, Levi S
2013 J Neurosci 33:15488-15503.

Molecular and functional characterization of GAD67-expressing, newborn granule cells in mouse dentate gyrus

Cabezas C, Irinopoulou T, Cauli B, Poncer JC
2013 Front Neural Circuits 7:60.

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